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吳怡眞

吳怡真

姓名
吳怡真

現職 
國立成功大學醫學院臨床醫學研究所副教授
國立成功大學附設醫院神經部主治醫師

學歷 
國立成功大學臨床醫學研究所博士
高雄醫學大學學士後醫學系
國立台灣大學職能治療學系

重要經歷
國立成功大學附設醫院神經部住院醫師，總醫師，臨床研究員
國立成功大學附設醫院斗六分院神經科主治醫師(08/2012-08/2014)
國立成功大學附設醫院神經部主治醫師(2014/9-)
國立中央大學認知神經科學研究所訪問研究員
英國倫敦大學神經學院訪問研究員
國立成功大學醫學院神經學科臨床助理教授(2018/2-2020/2)
美國凱斯西儲大學訪問研究學者(2019/3-5,2024-2025)
國立成功大學醫學院臨床醫學研究所助理教授(2020/2-2022/7)
國立成功大學醫學院臨床醫學研究所副教授(2022/8-)

證照
神經科專科醫師證書
醫師證書
迷走神經刺激術參數調整訓練訓練合格證書(2021-)

專長 
臨床神經學、癲癇學、神經電生理學、神經調節、認知神經科學

 

榮譽 
台灣癲癇學會癲癇研究論文獎佳作(2022)
成杏優秀論文獎(Top 10% paper, 2022)
全國兒童神經精神科學勵翔獎臨床組第一名(2022)
國立成功大學醫學院2021年新人最佳論文獎(2021)
台灣癲癇學會癲癇研究論文獎佳作(2021)
臺灣綜合大學系統年輕學者創新研發成果選拔佳作獎(2021)
科技部優秀年輕學者研究計畫(2019-2022)
台灣癲癇學會癲癇研究論文獎佳作(2020)
成大醫學院教學創新團體佳作(109學年度)
成杏優秀論文獎(2018)
成大醫學院博士論文競賽優勝(2017)
中華民國斐陶斐榮譽學會榮譽會員
成大醫院醫療科技研究計畫成果競賽獎(2015年基礎臨床組第二名, 2016年基礎臨床組第一名)
中央研究院跨領域神經科學暨國際研究生博士班學程出席國際會議壁報論文競賽獎
台灣神經醫學聯合學術研討會優秀壁報論文獎(2010年, 2012年, 2013年, 2015年, 2016年)
高雄醫學大學年度最佳實習醫師獎
國立台灣大學書卷獎

著作目錄

  1. CC Chiang, ME Chien, YC Huang, JT Lin, SF Liang, KS Hsu, DM Durand, and YJ Wu*. Cathodal weak direct current decreases epileptic excitability through reducing neuronal activity and enhancing delta oscillations. Journal of Physiology 2025Apr.7 Online ahead of print.
  2. Yu-Chieh Hung, Yi-Jen Wu, Miao-Er Chien, Yu-Ting Lin, Cheng-Fang Tsai, Kuei-Sen Hsu*. Loss of oxytocin receptors in hilar mossy cells impairs social discrimination. Neurobiology of Disease 2023;187:106311.
  3. Yi-Ting Fang†, Ye-Ting Lin†, Wu-Lung Tseng, Philip Tseng, Gia-Linh Hua, Ying-Jui Chao, Yi-Jen Wu*. Neuroimmunomodulation of vagus nerve stimulation and the therapeutic implications. Frontiers in Aging Neuroscience 2023 Jun 12, Accepted. (IF 5.702, Neurosciences 75.82%) (Corresponding Author)
  4. Chin-Hao Chen, Tsung-Chih Tsai, Yi-Jen Wu, Kuei-Sen Hsu*. Gastric vagal afferent signaling to the basolateral amygdala mediates anxiety-like behaviors in experimental colitis mice. JCI insight 2023 May 18;e161874. (IF 9.496, Medicine, Research & Experimental 19/139, 86.69%)
  5. Ting-Hsuan Yu, Yi-Jen Wu, Miao-Er Chien, Kuei-Sen Hsu* (2023, Jan). Multisession anodal transcranial direct current stimulation enhances adult hippocampal neurogenesis and context discrimination in mice. Journal of Neuroscience, 43(4):635-646.
  6. Yi-Ting Fang, Tsung-Lin Lee, Yi-Hsien Tu, Sheng-Hsiang Lin, Miao-Er Chien, Chin-Wei Huang, Kuei-Sen Hsu,Yi-Jen Wu* (2022, Jun). Factors associated with mortality in patients with super-refractory status epilepticus. Scientific Reports, 12:9670. (IF 4.38, SCI, Multidisciplinary Sciences 17/72, 77.08%) (通訊作者)
  7. 黃英儒主編,莊雯莉,呂明桂副主編等人.非侵入性腦刺激術-基礎、臨床與研究.民國111年9月初版.合記.吳怡真著,第11章,經顱直流電刺激的電生理與細胞分子機轉.
  8. Yi-Jen Wu*, Miao-Er Chien, Chia-Chu Chiang, Ying-Zu Huang, Dominique M Durand, Kuei-Sen Hsu* (2021, Jul-Aug). Delta oscillation underlies the interictal spike changes after repeated transcranial direct current stimulation in a rat model of chronic seizures. Brain Stimulation, 14(4): 771-779. (IF 8.955, SCI, Clinical Neurology 13/208, 93.99%; Neurosciences 19/273, 93.22%) (第一作者與通訊作者)
  9. Yi-Jen Wu*, Miao-Er Chien, Chih-Hsu Huang, Chia-Chu Chiang, Chou-Ching Lin, Chin-Wei Huang, Dominique M Durand, Kuei-Sen Hsu*(2020, Jun). Transcranial direct current stimulation alleviates seizure severity in kainic acid-induced status epilepticus rats. Experimental Neurology, 328:113264. (IF 5.33, SCI, Neurosciences 70/273, 74.54%) (第一作者與通訊作者)
  10. Ting-Hsuan Yu, Yi-Jen Wu, Miao-Er Chien, Kuei-Sen Hsu* (2019, Jan). Transcranial direct current stimulation induces hippocampal metaplasticity mediated by brain-derived neurotrophic factor. Neuropharmacology, 144:358-367. (IF 5.251, SCI, Pharmacology & Pharmacy 54/276, 80.62%; Neurosciences 72/273, 73.81%)
  11. Han-Wei Huang, Jing-Jane Tsai, Pei-Fang Su, Yu-Lin Mau, Yi-Jen Wu, Wen-Chi Wang, Chou-Ching K Lin*(2020, Apr). Cortical Excitability by Transcranial Magnetic Stimulation as Biomarkers for Seizure Controllability in Temporal Lobe Epilepsy, Neuromodulation, 23(3): 399-406. (IF 4.722, SCI, Clinical Neurology 54/208, 74.28%)
  12. Ming-Chi Lai, Te-Yu Hung, Kao-Min Lin, Pi-Shan Sung, Shyh-Jong Wu, Chih-Sheng Yang, Yi-Jen Wu, Jing-Jane Tsai, Sheng-Nan Wu*, Chin-Wei Huang* (2018, Jul). Sodium Metabisulfite: Effects on Ionic Currents and Excitotoxicity. Neurotoxicity Research, 34(1):1-15. (IF 3.911, SCI, Neurosciences 123/273, 55.13%)
  13. Yi-Jen Wu, Chou-Ching Lin, Che-Ming Yeh, Miao-Er Chien, Ming-Chung Tsao, Philip Tseng, Chin-Wei Huang, Kuei-Sen Hsu * (2017, Nov). Repeated transcranial direct current stimulation improves cognitive dysfunction and synaptic plasticity deficit in the prefrontal cortex of streptozotocin-induced diabetic rats. Brain Stimulation, 10(6):1079-1087. (IF 8.955, SCI, Clinical Neurology 13/208, 93.99%; Neurosciences 19/273, 93.22%). (第一作者)
  14. Yi-Jen Wu, Philip Tseng, Han-Wei Huang, Jon-Fan Hu, Chi-Hung Juan, Kuei-Sen Hsu, Chou-Ching Lin* (2016, Sep). The Facilitative Effect of Transcranial Direct Current Stimulation on Visuospatial Working Memory in Patients with Diabetic Polyneuropathy: A Pre– post Sham-Controlled Study. Frontiers in Human Neuroscience, 2016;10:479- 489. (IF 3.169, SCI, Psychology 27/77, 65.58%). (第一作者)
  15. Ming-Chi Lai, Kao-Min Lin, Jing-Jane Tsai, Yi-Jen Wu, Chin-Wei Huang *. (2016, Dec). Dupuytren’s contracture: subacute onset after long-term antiepileptic drug use. Neuropsychiatry, 6(6), 366-368. (IF 1.456)

  16. Yi-Jen Wu, Philip Tseng, Chi-Fu Chang, Ming-Chyi Pai, Kuei-Sen Hsu, Chou-Ching Lin*, Chi-Hung Juan* (2014, Nov). Modulating the interference effect on spatial working memory by applying transcranial direct current stimulation over the right dorsolateral prefrontal cortex. Brain and Cognition, 91:87-94. (IF 2.310, SCI, Psychology, Experimental 51/91, 44.51%). (第一作者)

  17. Yi-Jen Wu, Chou-Ching Lin* (2013, Feb). Cold-induced eyelid myotonia. Neurology, 80(8):e81. (IF 9.910, SCI, Clinical Neurology 12/208, 94.47%). (第一作者)
  18. Julie Chi Chow, Chin-Wei Huang*, Chen-Wen Fang, Yi-Jen Wu, Jing-Jane Tsai (2013, Jan). Lamotrigine induced hypersensitivity syndrome in a Han Chinese patient with the HLAB*5801 genotype. Neurological Sciences, 34(1):117-9. (IF 3.307, SCI, Clinical Neurology 103/208, 50.72%).
  19. Yi-Jen Wu, Ming-Chyi Pai* (2012, Jul). Two gloves and one sock syndrome after a pontine hemorrhage. Neurologist, 18(4):196-8. (IF 1.398, SCI, Clinical Neurology 190/208, 8.89%). (第一作者)
  20. Yi-Jen Wu, Tzu-Tung Tsai, Chin-Wei Huang* (2011, Sep). Conjugate eye deviation shifting in hemispheric stroke indicates an emerging mass effect. Journal of Clinical Neuroscience, 18(9):1276-8. (IF 1.961, SCI, Clinical Neurology 167/208, 19.95%). (第一作者)
  21. Cheng-Yang Hsieh, Nan-Jin Chiou, Yi-Jen Wu, Jing-Jane Tsai, Chin-Wei Huang* (2011, Apr). Somatosensory rub evoked reflex epilepsy of a temporal lobe origin. Neurological Sciences, 32(2):297-9. (IF 3.307, SCI, Clinical Neurology 103/208, 50.72%).
  22. Chin-Wei Huang, Yi-Jen Wu, Sheng-Nan Wu* (2011, Mar). Modification of activation kinetics of delayed rectifier K+ currents and neuronal excitability by methyl-β-cyclodextrin. Neuroscience, 176:431-41. (IF 3.590, SCI, Neurosciences 141/273, 48.53%).
  23. Yi-Jen Wu, Ming-Chi Lai, Chin-Wei Huang* (2010, Dec). Reversible postvaccination paraneoplastic encephalomyelitis in a patient with lung adenocarcinoma. International Journal of Neuroscience, 120(12):792-5. (IF 2.292, SCI, Neurosciences 219/273, 19.96%). (第一作者)
  24. Yi-Jen Wu, Jing-Jane Tsai, Chin-Wei Huang* (2010, Nov). Nonketotic hyperglycemia-related reflex epileptic seizures induced by Mah-Jong playing. Epilepsy & Behavior, 19(3):533-5. (IF 2.937, SCI, Behavioral Sciences 26/53, 51.89%) (第一作者)

專書章節

黃英儒主編,莊雯莉,呂明桂副主編等人.非侵入性腦刺激術-基礎、臨床與研究.民國111年9月初版.合記. 吳怡真著 第11章,經顱直流電刺激的電生理與細胞分子機轉.

專利

Title of Invention: A method for detection of high-density epileptic spikes. Inventor: YJ Wu*, SF Liang, JT Lin. (No: I876981, Taiwan, 2025/3/11-2044/5/5)

網頁        https://sites.google.com/view/yjw-lab/home?authuser=0

ORCID   https://orcid.org/0000-0002-4369-1791

E-mail       wuyj@mail.ncku.edu.tw

 

 

 
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