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Yi-Jen Wu

Yi-Jen Wu

Yi-Jen Wu, MD., PhD.

 

Appointment       

Associate Professor, Institute of Clinical Medicine, College of Medicine, National Cheng Kung University

Attending Neurologist, Department of Neurology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University

 

Specialty
Clinical Neurology, Seizure/Epilepsy, Electroneurophysiology, Neuromodulation, Cognitive Neuroscience

 

Education

Ph.D., Clinical Medicine, National Cheng Kung University

M.D., Medicine, Kaohsiung Medical University

B.S., Occupational Therapy, National Taiwan University

 

Professional Position

1. Resident and Clinical Fellow, Dept. of Neurology, National Cheng Kung University Hospital
2. Attending Physician, Div. of Neurology, National Cheng Kung University, Dou-Liou Branch (08/2012-08/2014)
3. Attending Physician, Dept. of Neurology, National Cheng Kung University (2014/9-)
4. Visiting Researcher, Institute of Cognitive Neuroscience, National Central University, Taiwan
5. Visiting Researcher, Institute of Neurology, UCL, Queen Square, London, UK
6. Clinical Assistant Professor, Neurology, College of Medicine, National Cheng Kung University(2018/2-2020/2)
7. Visiting Assistant Professor, Dept. Biomedical Engineering, Case Western Reserve University, USA(2019/3-5)
8. Assistant Professor, Institute of Clinical Medicine, College of Medicine, National Cheng Kung University (2020/2-2022/7)
9. Associate Professor, Institute of Clinical Medicine, College of Medicine, National Cheng Kung University (2022/8-)

 

Licensure and Certification

Neurology Board, Taiwan 
Physician Board, Taiwan
Vagus Nerve Stimulation, Parameter Setting Training Course Certificate (2021-)

 

Research Interests

Brain Stimulation (Clinical Applications, Neurophysiological Mechanism, tDCS, VNS, DBS)
Seizure and Epileptology 
Cognitive Neuroscience

 

Awards

  • Academic Distinction Award, National Taiwan University (1998)
  • Best Intern, Kaohsiung Medical University (2007)
  • Poster Presentation Award, Annual Conference of Taiwan Neurological Society (2010, 2012, 2013, 2015, 2016)
  • International Conference Travel Fellowship Award, TIGP-INS, Neuroscience Program in Academia Sinica (2015)
  • National Cheng Kung University Hospital Research Project Competition Award (Clinical/Basic Research, 2015 Second Prize, 2016 First Prize)
  • Ph.D. Dissertation Award of College of Medicine, National Cheng Kung University (2017)
  • The Phi Tau Phi Scholastic Honor Society Honorary Membership (2017)
  • Academic Paper Award, Cheng-Hsing Medical Foundation (2018)
  • NCKU Medical College Teaching Innovativeness Honorable Mention Award (2020)
  • Taiwan Epilepsy Society Research Paper Honorable Mention Award (2020)
  • Outstanding Young Scholars Research Grant, Ministry of Science and Technology, Taiwan (2019-2022)
  • Young Scholar Innovative Research Competition, Honorable Mention Award, Taiwan Comprehensive University System (2021)
  • Taiwan Epilepsy Society Research Paper Honorable Mention Award (2021)
  • Young Investigator Research Award in Clinical Medicine, Medical College, National Cheng Kung University (2021)
  • Young Investigator Award for Pediatric Neuropsychiatric Science (2022)
  • Academic Paper Award, Cheng-Hsing Medical Foundation (Top 10% paper, 2022)
  • Taiwan Epilepsy Society Research Paper Honorable Mention Award (2022)

Publications

  1. Yu-Chieh Hung, Yi-Jen Wu, Miao-Er Chien, Yu-Ting Lin, Cheng-Fang Tsai, Kuei-Sen Hsu*. Loss of oxytocin receptors in hilar mossy cells impairs social discrimination. Neurobiology of Disease 2023;187:106311.
  2. Yi-Ting Fang†, Ye-Ting Lin†, Wu-Lung Tseng, Philip Tseng, Gia-Linh Hua, Ying-Jui Chao, Yi-Jen Wu*. Neuroimmunomodulation of vagus nerve stimulation and the therapeutic implications. Frontiers in Aging Neuroscience 2023 Jun 12, Accepted. (IF 5.702, Neurosciences 75.82%) (Corresponding Author)
  3. Chin-Hao Chen, Tsung-Chih Tsai, Yi-Jen Wu, Kuei-Sen Hsu*. Gastric vagal afferent signaling to the basolateral amygdala mediates anxiety-like behaviors in experimental colitis mice. JCI insight 2023 May 18;e161874. (IF 9.496, Medicine, Research & Experimental 19/139, 86.69%)
  4. Ting-Hsuan Yu, Yi-Jen Wu, Miao-Er Chien, Kuei-Sen Hsu* (2023, Jan). Multisession anodal transcranial direct current stimulation enhances adult hippocampal neurogenesis and context discrimination in mice. Journal of Neuroscience, 43(4):635-646.
  5. Yi-Ting Fang, Tsung-Lin Lee, Yi-Hsien Tu, Sheng-Hsiang Lin, Miao-Er Chien, Chin-Wei Huang, Kuei-Sen Hsu, Yi-Jen Wu* (2022, Jun). Factors associated with mortality in patients with super-refractory status epilepticus. Scientific Reports, 12:9670. (IF 4.38, SCI, Multidisciplinary Sciences 17/72, 77.08%) (Corresponding Author)
  6. 黃英儒主編,莊雯莉,呂明桂副主編等人.非侵入性腦刺激術-基礎、臨床與研究.民國111年9月初版.合記.吳怡真著,第11章,經顱直流電刺激的電生理與細胞分子機轉.
  7. Yi-Jen Wu*, Miao-Er Chien, Chia-Chu Chiang, Ying-Zu Huang, Dominique M Durand, Kuei-Sen Hsu* (2021, Jul-Aug). Delta oscillation underlies the interictal spike changes after repeated transcranial direct current stimulation in a rat model of chronic seizures. Brain Stimulation, 14(4): 771-779. (IF 8.955, SCI, Clinical Neurology 13/208, 93.99%; Neurosciences 19/273, 93.22%) (First & Corresponding Author)
  8. Yi-Jen Wu*, Miao-Er Chien, Chih-Hsu Huang, Chia-Chu Chiang, Chou-Ching Lin, Chin-Wei Huang, Dominique M Durand, Kuei-Sen Hsu*(2020, Jun). Transcranial direct current stimulation alleviates seizure severity in kainic acid-induced status epilepticus rats. Experimental Neurology, 328:113264. (IF 5.33, SCI, Neurosciences 70/273, 74.54%) (First & Corresponding Author)
  9. Ting-Hsuan Yu, Yi-Jen Wu, Miao-Er Chien, Kuei-Sen Hsu* (2019, Jan). Transcranial direct current stimulation induces hippocampal metaplasticity mediated by brain-derived neurotrophic factor. Neuropharmacology, 144:358-367. (IF 5.251, SCI, Pharmacology & Pharmacy 54/276, 80.62%; Neurosciences 72/273, 73.81%)
  10. Han-Wei Huang, Jing-Jane Tsai, Pei-Fang Su, Yu-Lin Mau, Yi-Jen Wu, Wen-Chi Wang, Chou-Ching K Lin*(2020, Apr). Cortical Excitability by Transcranial Magnetic Stimulation as Biomarkers for Seizure Controllability in Temporal Lobe Epilepsy, Neuromodulation, 23(3): 399-406. (IF 4.722, SCI, Clinical Neurology 54/208, 74.28%)
  11. Ming-Chi Lai, Te-Yu Hung, Kao-Min Lin, Pi-Shan Sung, Shyh-Jong Wu, Chih-Sheng Yang, Yi-Jen Wu, Jing-Jane Tsai, Sheng-Nan Wu*, Chin-Wei Huang* (2018, Jul). Sodium Metabisulfite: Effects on Ionic Currents and Excitotoxicity. Neurotoxicity Research, 34(1):1-15. (IF 3.911, SCI, Neurosciences 123/273, 55.13%)
  12. Yi-Jen Wu, Chou-Ching Lin, Che-Ming Yeh, Miao-Er Chien, Ming-Chung Tsao, Philip Tseng, Chin-Wei Huang, Kuei-Sen Hsu * (2017, Nov). Repeated transcranial direct current stimulation improves cognitive dysfunction and synaptic plasticity deficit in the prefrontal cortex of streptozotocin-induced diabetic rats. Brain Stimulation, 10(6):1079-1087. (IF 8.955, SCI, Clinical Neurology 13/208, 93.99%; Neurosciences 19/273, 93.22%). (First Author)
  13. Yi-Jen Wu, Philip Tseng, Han-Wei Huang, Jon-Fan Hu, Chi-Hung Juan, Kuei-Sen Hsu, Chou-Ching Lin* (2016, Sep). The Facilitative Effect of Transcranial Direct Current Stimulation on Visuospatial Working Memory in Patients with Diabetic Polyneuropathy: A Pre– post Sham-Controlled Study. Frontiers in Human Neuroscience, 2016;10:479- 489. (IF 3.169, SCI, Psychology 27/77, 65.58%). (First Author)
  14. Ming-Chi Lai, Kao-Min Lin, Jing-Jane Tsai, Yi-Jen Wu, Chin-Wei Huang *. (2016, Dec). Dupuytren’s contracture: subacute onset after long-term antiepileptic drug use. Neuropsychiatry, 6(6), 366-368. (IF 1.456)
  15. Yi-Jen Wu, Philip Tseng, Chi-Fu Chang, Ming-Chyi Pai, Kuei-Sen Hsu, Chou-Ching Lin*, Chi-Hung Juan* (2014, Nov). Modulating the interference effect on spatial working memory by applying transcranial direct current stimulation over the right dorsolateral prefrontal cortex. Brain and Cognition, 91:87-94. (IF 2.310, SCI, Psychology, Experimental 51/91, 44.51%). (First Author)
  16. Yi-Jen Wu, Chou-Ching Lin* (2013, Feb). Cold-induced eyelid myotonia. Neurology, 80(8):e81. (IF 9.910, SCI, Clinical Neurology 12/208, 94.47%). (First Author)
  17. Julie Chi Chow, Chin-Wei Huang*, Chen-Wen Fang, Yi-Jen Wu, Jing-Jane Tsai (2013, Jan). Lamotrigine induced hypersensitivity syndrome in a Han Chinese patient with the HLAB*5801 genotype. Neurological Sciences, 34(1):117-9. (IF 3.307, SCI, Clinical Neurology 103/208, 50.72%).
  18. Yi-Jen Wu, Ming-Chyi Pai* (2012, Jul). Two gloves and one sock syndrome after a pontine hemorrhage. Neurologist, 18(4):196-8. (IF 1.398, SCI, Clinical Neurology 190/208, 8.89%). (First Author)
  19. Yi-Jen Wu, Tzu-Tung Tsai, Chin-Wei Huang* (2011, Sep). Conjugate eye deviation shifting in hemispheric stroke indicates an emerging mass effect. Journal of Clinical Neuroscience, 18(9):1276-8. (IF 1.961, SCI, Clinical Neurology 167/208, 19.95%). (First Author)
  20. Cheng-Yang Hsieh, Nan-Jin Chiou, Yi-Jen Wu, Jing-Jane Tsai, Chin-Wei Huang* (2011, Apr). Somatosensory rub evoked reflex epilepsy of a temporal lobe origin. Neurological Sciences, 32(2):297-9. (IF 3.307, SCI, Clinical Neurology 103/208, 50.72%).
  21. Chin-Wei Huang, Yi-Jen Wu, Sheng-Nan Wu* (2011, Mar). Modification of activation kinetics of delayed rectifier K+ currents and neuronal excitability by methyl-β-cyclodextrin. Neuroscience, 176:431-41. (IF 3.590, SCI, Neurosciences 141/273, 48.53%).
  22. Yi-Jen Wu, Ming-Chi Lai, Chin-Wei Huang* (2010, Dec). Reversible postvaccination paraneoplastic encephalomyelitis in a patient with lung adenocarcinoma. International Journal of Neuroscience, 120(12):792-5. (IF 2.292, SCI, Neurosciences 219/273, 19.96%). (First Author)
  23. Yi-Jen Wu, Jing-Jane Tsai, Chin-Wei Huang* (2010, Nov). Nonketotic hyperglycemia-related reflex epileptic seizures induced by Mah-Jong playing. Epilepsy & Behavior, 19(3):533-5. (IF 2.937, SCI, Behavioral Sciences 26/53, 51.89%) (First Author)

Website https://sites.google.com/view/yjw-lab/home?authuser=0

ORCID https://orcid.org/0000-0002-4369-1791

E-mail     wuyj@mail.ncku.edu.tw