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  4. Yi-Jen Wu

Yi-Jen Wu

Yi-Jen Wu

Yi-Jen Wu, MD., PhD.

 

Current Affiliation       

Associate Professor, Institute of Clinical Medicine, College of Medicine, National Cheng Kung University

Attending Neurologist, Department of Neurology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University

 

Specialty

Neurology, Seizure/Epilepsy, Neurophysiology, Neuromodulation, Cognitive Neuroscience

 

Education

Ph.D., Clinical Medicine, National Cheng Kung University

M.D., Medicine, Kaohsiung Medical University

B.S., Occupational Therapy, National Taiwan University

 

 

Professional Position

Resident and Clinical Fellow, Dept. of Neurology, National Cheng Kung University Hospital

Attending Physician, Div. of Neurology, National Cheng Kung University, Dou-Liou Branch (2012/8-2014/8)

Attending Physician, Dept. of Neurology, National Cheng Kung University Hospital (2014/9-present)

Visiting Researcher, Institute of Cognitive Neuroscience, National Central University, Taiwan

Visiting Researcher, Institute of Neurology, UCL, Queen Square, London, UK

Clinical Assistant Professor, Neurology, College of Medicine, National Cheng Kung University (2018/2-2020/2)

Visiting Assistant Professor, Dept. Biomedical Engineering, Case Western Reserve University, USA (2019/3-5)

Assistant Professor, Institute of Clinical Medicine, College of Medicine, National Cheng Kung University (2020/2-2022/7)

Visiting Associate Professor, Dept. Biomedical Engineering, Case Western Reserve University, USA (2024/3-2025/2)

Associate Professor, Institute of Clinical Medicine, College of Medicine, National Cheng Kung University (2022/8-present)

 

Licensure and Certification

Neurology Board, Taiwan
Physician Board, Taiwan

 

Awards

Academic Distinction Award, National Taiwan University (1998)

Best Intern, Kaohsiung Medical University (2007)

Poster Presentation Award, Annual Conference of Taiwan Neurological Society (2010, 2012, 2013, 2015, 2016)

International Conference Travel Fellowship Award, TIGP-INS, Neuroscience Program in Academia Sinica (2015)

National Cheng Kung University Hospital Research Project Competition Award (Clinical/Basic Research, 2015 Second Prize, 2016 First Prize)

Ph.D. Dissertation Award of College of Medicine, National Cheng Kung University (2017)

The Phi Tau Phi Scholastic Honor Society Honorary Membership (2017)

Academic Paper Award, Cheng-Hsing Medical Foundation (2018)

NCKU Medical College Teaching Innovativeness Honorable Mention Award (2020)

Taiwan Epilepsy Society Research Paper Honorable Mention Award (2020)

Outstanding Young Scholars Research Grant, Ministry of Science and Technology, Taiwan (2019-2022)

Young Scholar Innovative Research Competition, Honorable Mention Award, Taiwan Comprehensive University System (2021)

Taiwan Epilepsy Society Research Paper Honorable Mention Award (2021)

Young Scholar Best Paper Award, Medical College, National Cheng Kung University (2021)

Young Investigator Award for Pediatric Neuropsychiatric Science (2022)

Academic Paper Award, Cheng-Hsing Medical Foundation (Top 10% paper, 2022)

Taiwan Epilepsy Society Research Paper Honorable Mention Award (2022)

 

Publications

  1. PH Wu, ME Chien, YJ Wu*, CH Fan*. Focused ultrasound combined with drug-loaded microbubbles suppresses ictal spikes in kainic acid-induced epileptic animals. Ultrasonics Sonochemistry 2025; 120:107518. (Acoustics 1/41, 98.8%, IF 9.7)
  2. CC Chiang, ME Chien, YC Huang, JT Lin, SF Liang, KS Hsu, DM Durand, and YJ Wu*. Cathodal weak direct current decreases epileptic excitability through reducing neuronal activity and enhancing delta oscillations. Journal of Physiology 2025; 603(9):2763-2782. (Physiology 10/87, 89.1%, IF 4.4)
  3. YC Hung, YJ Wu, ME Chien, YT Lin, CF Tsai, KS Hsu*. Loss of oxytocin receptors in hilar mossy cells impairs social discrimination. Neurobiology of Disease 2023;187:106311.
  4. YT Fang, YT Lin, WL Tseng, P Tseng, GL Hua, YJ Chao, YJ Wu*. Neuroimmunomodulation of vagus nerve stimulation and the therapeutic implications. Frontiers in Aging Neuroscience 2023;15:1173987.
  5. CH Chen, TC Tsai, YJ Wu, KS Hsu*. Gastric vagal afferent signaling to the basolateral amygdala mediates anxiety-like behaviors in experimental colitis mice. JCI Insight 2023;8(22):e161874.
  6. TH Yu, YJ Wu, ME Chien, KS Hsu*. Multisession anodal transcranial direct current stimulation enhances adult hippocampal neurogenesis and context discrimination in mice. Journal of Neuroscience 2023;43(4):635-646.
  7. YT Fang, TL Lee, YH Tu, SH Lin, ME Chien, CW Huang, KS Hsu, YJ Wu*. Factors associated with mortality in patients with super-refractory status epilepticus. Scientific Reports 2022;12:9670.
  8. YJ Wu*, ME Chien, CC Chiang, YZ Huang, DM Durand, KS Hsu*. Delta oscillation underlies the interictal spike changes after repeated transcranial direct current stimulation in a rat model of chronic seizures. Brain Stimulation 2021;14(4): 771-779.
  9. YJ Wu*, ME Chien, CH Huang, CC Chiang, CC Lin, CW Huang, DM Durand, KS Hsu*. Transcranial direct current stimulation alleviates seizure severity in kainic acid-induced status epilepticus rats. Experimental Neurology 2020;328:113264.
  10. TH Yu, YJ Wu, ME Chien, KS Hsu*. Transcranial direct current stimulation induces hippocampal metaplasticity mediated by brain-derived neurotrophic factor. Neuropharmacology 2019;144:358-367.
  11. HW Huang, JJ Tsai, PF Su, YL Mau, YJ Wu, WC Wang, CC Lin*. Cortical Excitability by Transcranial Magnetic Stimulation as Biomarkers for Seizure Controllability in Temporal Lobe Epilepsy, Neuromodulation 2020;23(3): 399-406.
  12. MC Lai, TY Hung, KM Lin, PS Sung, SJ Wu, CS Yang, YJ Wu, JJ Tsai, SN Wu*, CW Huang*. Sodium Metabisulfite: Effects on Ionic Currents and Excitotoxicity. Neurotoxicity Research 2018;34(1):1-15.
  13. YJ Wu, CC Lin, CM Yeh, ME Chien, MC Tsao, P Tseng, CW Huang, KS Hsu*. Repeated transcranial direct current stimulation improves cognitive dysfunction and synaptic plasticity deficit in the prefrontal cortex of streptozotocin-induced diabetic rats. Brain Stimulation 2017;10(6):1079-1087.
  14. YJ Wu, P Tseng, HW Huang, JF Hu, CH Juan, KS Hsu, CC Lin*. The Facilitative Effect of Transcranial Direct Current Stimulation on Visuospatial Working Memory in Patients with Diabetic Polyneuropathy: A Pre– post Sham-Controlled Study. Frontiers in Human Neuroscience 2016;10:479- 489.
  15. MC Lai, KM Lin, JJ Tsai, YJ Wu, CW Huang*. Dupuytren’s contracture: subacute onset after long-term antiepileptic drug use. Neuropsychiatry, 2016;6(6), 366-368.
  16. YJ Wu, P Tseng, CF Chang, MC Pai, KS Hsu, CC Lin*, CH Juan*. Modulating the interference effect on spatial working memory by applying transcranial direct current stimulation over the right dorsolateral prefrontal cortex. Brain and Cognition 2014;91:87-94.
  17. YJ Wu, CC Lin*. Cold-induced eyelid myotonia. Neurology 2013;80(8):e81.
  18. JC Chow, CW Huang*, CW Fang, YJ Wu, JJ Tsai. Lamotrigine induced hypersensitivity syndrome in a Han Chinese patient with the HLAB*5801 genotype. Neurological Sciences, 2013;34(1):117-9.
  19. YJ Wu, MC Pai*. Two gloves and one sock syndrome after a pontine hemorrhage. Neurologist 2012;18(4):196-8.
  20. YJ Wu, TT Tsai, CW Huang*. Conjugate eye deviation shifting in hemispheric stroke indicates an emerging mass effect. Journal of Clinical Neuroscience 2011;18(9):1276-8.
  21. CY Hsieh, NJ Chiou, YJ Wu, JJ Tsai, CW Huang* (2011, Apr). Somatosensory rub evoked reflex epilepsy of a temporal lobe origin. Neurological Sciences 2011;32(2):297-9.
  22. CW Huang, YJ Wu, SN Wu*. Modification of activation kinetics of delayed rectifier K+ currents and neuronal excitability by methyl-β-cyclodextrin. Neuroscience 2011;176:431-41.
  23. YJ Wu, MC Lai, CW Huang*. Reversible postvaccination paraneoplastic encephalomyelitis in a patient with lung adenocarcinoma. International Journal of Neuroscience 2010;120(12):792-5.
  24. YJ Wu, JJ Tsai, CW Huang*. Nonketotic hyperglycemia-related reflex epileptic seizures induced by Mah-Jong playing. Epilepsy & Behavior, 2010;19(3):533-5.

 

Book Chapter

Yi-Jen Wu (2022). Electrophysiological and cellular mechanisms of transcranial direct current stimulation. In Ying-Zu Huang (1st Ed.). Noninvasive Brain Stimulation: Basic, Clinical, and Research (pp. 147-160). Taipei, Taiwan: Ho-Chi Publishing.

 

Patents

Title of Invention: A method for detection of high-density epileptic spikes. Inventor: YJ Wu*, SF Liang, JT Lin (No: I876981, Taiwan, 2025/3/11-2044/5/5).

 

Society

Board Member, Taiwan Society of Clinical Neurophysiology (2022/8-)

Secretary General, Taiwan Society of Clinical Neurophysiology (2025/8-)

Board Member, Tainan Epilepsy Association (2018/1-)

Academic Committee Member, Taiwan Neurological Society (2025-present)

Education Committee Member, Taiwan Neurological Society (2021-present)

Research & Development Committee Member, Taiwan Epilepsy Society (2023- present)

Education Committee Member, Taiwan Epilepsy Society (2021-23)

Member: Society for Neuroscience, American Epilepsy Society, Taiwan Neurological Society, Taiwan Epilepsy Society, Taiwan Society of Clinical Neurophysiology, Taiwan Neuroscience Society

 

Websitehttps://sites.google.com/view/yjw-lab

ORCID https://orcid.org/0000-0002-4369-1791

E-mail    wuyj@mail.ncku.edu.tw

 

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