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Yi-Jen Wu

Yi-Jen Wu, M.D., Ph.D.



Attending Neurologist and Clinical Assistant Professor, Department of Neurology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University

Joint-Appointment Adjunct Assistant Professor, Institute of Clinical Medicine, College of Medicine, National Cheng Kung University



Clinical Neurology, Electroneurophysiology, Epileptology, Cognitive Neuroscience



Ph.D., Clinical Medicine, National Cheng Kung University

M.D., Medicine, Kaohsiung Medical University

B.S., Occupational Therapy, National Taiwan University


Professional Training

Resident, Dept. of Neurology, National Cheng Kung University Hospital

Clinical Fellow, Dept. of Neurology, National Cheng Kung University Hospital

Attending Physician, Div. of Neurology, National Cheng Kung University, Dou-Liou Branch

Attending Physician, Dept. of Neurology, National Cheng Kung University

Visiting research member, Institute of Cognitive Neuroscience, National Central University, Taiwan

Visiting research member, Institute of Neurology, UCL, Queen Square, London, UK


Licensure and Certification

Neurology Board, Taiwan
Physician Board, Taiwan
Occupational Therapist Registered/Licensed Certification, Taiwan


Research Interests

Noninvasive Brain Stimulation (Clinical Applications, Neurophysiological Mechanism)
Cognitive Neuroscience



Academic Distinction Award, National Taiwan University (1998)
Best Intern, Kaohsiung Medical University (2007)
Poster Presentation Award, Annual Conference of Taiwan Neurological Society (2010, 2012, 2013, 2015, 2016)
International Conference Travel Fellowship Award, TIGP-INS, Neuroscience Program in Academia Sinica (2015)
National Cheng Kung University Hospital Research Project Competition Award (Clinical/Basic Research, 2015 Second Prize, 2016 First Prize)

Ph.D. Dissertation Award of College of Medicine, National Cheng Kung University (2017)

The Phi Tau Phi Scholastic Honor Society Honorary Membership (2017)

Academic Paper Award, Cheng-Hsing Medical Foundation (2018)



Theme 1: Transcranial Direct Current Stimulation, Clinical and Basic Researches

  1. Wu YJ, Tseng P, Chang CF, Pai MC, Hsu KS, Lin CC*, Juan CH* (2014, Nov). Modulating the interference effect on spatial working memory by applying transcranial direct current stimulation over the right dorsolateral prefrontal cortex. Brain and Cognition, 91:87-94. (IF 2.432)
  2. Wu YJ, Tseng P, Huang HW, Hu JF, Juan CH, Hsu KS, Lin CC*. (2016, Sep). The Facilitative Effect of Transcranial Direct Current Stimulation on Visuospatial Working Memory in Patients with Diabetic Polyneuropathy: A Pre–Post Sham-Controlled Study. Frontiers in Human Neuroscience, 10:479-489. (IF 3.634)
  3. Wu YJ, Lin CC, Yeh CM, Chien ME, Tsao MC, Tseng P, Huang CW, Hsu KS* (2017, Nov). Repeated transcranial direct current stimulation improves cognitive dysfunction and synaptic plasticity deficit in the prefrontal cortex of streptozotocin-induced diabetic rats. Brain Stimulation, 10(6):1079-1087. (IF 6.078)
  4. Yu TH, Wu YJ, Chien ME, Hsu KS*(2018, Nov). Transcranial direct current stimulation induces hippocampal metaplasticity mediated by brain-derived neurotrophic factor. Neuropharmacology, 144:358-367. (IF 4.249)
  5. Wu YJ*, Chien ME, Huang CH, Chiang CC, Lin CC, Huang CW, Durand DM, Hsu KS*(2020, Feb). Transcranial direct current stimulation alleviates seizure severity in kainic acid-induced status epilepticus rats. Experimental Neurology, 328:113264. (IF 4.562)


Theme 2: Seizure and Epilepsy, Clinical and Basic Studies

  1. Wu YJ, Tsai JJ, Huang CW* (2010, Nov). Nonketotic hyperglycemia-related reflex epileptic seizures induced by Mah-Jong playing. Epilepsy & Behavior, 19(3):533-5. (SCI)
  2. Hsieh CY, Chiou NJ, Wu YJ, Tsai JJ, Huang CW* (2011, Apr). Somatosensory rub evoked reflex epilepsy of a temporal lobe origin. Neurological Sciences, 32(2):297-9. (SCI)
  3. Huang CW, Wu YJ, Wu SN* (2011, Mar). Modification of activation kinetics of delayed rectifier K+ currents and neuronal excitability by methyl-β-cyclodextrin. Neuroscience, 176:431-41. (SCI)
  4. Chow JC, Huang CW*, Fang CW, Wu YJ, Tsai JJ (2013, Jan). Lamotrigineinduced hypersensitivity syndrome in a Han Chinese patient with the HLAB*5801 genotype. Neurological Sciences, 34(1):117-9. (SCI)
  5. Lai MC, Lin KM, Tsai JJ, Wu YJ, Huang CW*. (2016, Dec). Dupuytren’s contracture: subacute onset after long-term antiepileptic drug use. Neuropsychiatry, 6(6), 366-368. (SCI)
  6. Lai MC, Hung TY, Lin KM, Sung PS, Wu SJ, Yang CS, Wu YJ, Tsai JJ, Wu SN†, Huang CW*. (2017, Nov). Sodium Metabisulfite: Effects on Ionic Currents and Excitotoxicity. Neurotoxicity Research, Neurotox Res (2017). (SCI)
  7. Huang HW, Tsai JJ, Su PF, Mau YL, Wu YJ, Wang WC, Lin CK* (2019, Dec). Cortical Excitability by Transcranial Magnetic Stimulation as Biomarkers for Seizure Controllability in Temporal Lobe Epilepsy. Neuromodulation. (SCI)


Theme 3: Clinical Neurology Studies

  1. Wu YJ, Lin CC* (2013, Feb). Cold-induced eyelid myotonia. Neurology, 80(8):e81. (SCI, IF 8.166)
  2. Wu YJ, Pai MC* (2012, Jul). Two gloves and one sock syndrome after a pontine hemorrhage. Neurologist, 18(4):196-8. (SCI)
  3. Wu YJ, Tsai TT, Huang CW* (2011, Sep). Conjugate eye deviation shifting in hemispheric stroke indicates an emerging mass effect. Journal of Clinical Neuroscience, 18(9):1276-8. (SCI)
  4. Wu YJ, Lai ML, Huang CW* (2010, Dec). Reversible postvaccination paraneoplastic encephalomyelitis in a patient with lung adenocarcinoma. International Journal of Neuroscience, 120(12):792-5. (SCI)


Website  http://wuyj.weebly.com/