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Pi-Shan Sung

Name: Pi-Shan Sung

Chronology of position held:

Aug. 2018 to present            Clinical Assistant professor, Department of  Neurology,

                                                National Cheng Kung University Hospital, Tainan, Taiwan

Aug. 2010 to present            Staff Physician, Department of Neurology,

                                                National Cheng Kung University Hospital, Tainan, Taiwan.

Aug. 2009- July 2010            Chief Resident, Department of Neurology,

                                                National Cheng Kung University Hospital, Tainan, Taiwan.

July 2006- July 2009             Resident, Department of Neurology,

                                                National Cheng Kung University Hospital, Tainan, Taiwan.

Education:

1999-2006               Doctor of Medicine, National Cheng Kung University

2012~                      The institute of clinical medicine, National Cheng Kung University

Board Certification:

2010               Specialty Board of Neurology, Taiwan.  

2006                Board of Doctor, Taiwan.

Society Memberships:

        Member,    Formosan Medical Association

        Member,   Neurology Association, Taiwan.

    Member,   Taiwan Stroke Association

  

Publication:

Referred paper:

  1. Memantine Protects against Paclitaxel-Induced Cognitive Impairment through Modulation of Neurogenesis and Inflammation in Mice. Pi-Shan Sung, Pei-Wen Chen, Chia-Jui Yen, Meng-Ru Shen, Chih-Hung Chen, Kuen-Jer Tsai*, and  Chou-Ching K. Lin* Cancers 2021, 13(16), 4177（First author）
  2. Hypoperfusion Index Ratio as a Surrogate of Collateral Scoring on CT Angiogram in Large Vessel Stroke. Wang CM, Chang YM, Sung PS, Chen CH. J Clin Med. 2021. 21;10(6):1296.  (Corresponding author).
  3. Factors Associated with Cognitive Outcomes After First-Ever Ischemic Stroke: The Impact of Small Vessel Disease Burden and Neurodegeneration. Sung PS, Lee KP, Lin PY, Su HC, Yu RL, Tsai KJ, Lin SH, Chen CH.J Alzheimers Dis. 2021 Jul 27. doi: 10.3233/JAD-210587. (Co-first author)
  4. Simple but organized neurology residency training improves the quality of acute stroke care: From the outset to long-term effect. Yu Ming Chang, Chun Min Wang, Po Yu Lin, Pi Shan Sung, Sheng Hsiang Lin, Chih-Hung Chen.  Journal of Stroke, 23(2), 293-295. https://doi.org/10.5853/jos.2020.04910 (Corresponding Author)
  5. Association between Blood Pressure, Blood Pressure Variability, and Post-Stroke Cognitive Impairment. Kang-Po Lee, Alice Y. W. Chang, Pi-Shan Sung. Biomedicines 2021, 9(7), 773 (Corresponding Author)
  6. Hypoperfusion Index Ratio as a Surrogate of Collateral Scoring on CT Angiogram in Large Vessel Stroke. Chun-Min Wang, Yu-Ming Chang *, Pi-Shan Sung * and Chih-Hung Chen. J. Clin. Med. 2021, 10, 1296. (Corresponding Author)
  7. Po-Yu Lin,Yu-Ming Chang, Chih-Yuan Huang, Chih-Hao Lin, Ming-Tsung Chuang, Po-Lin Chen, Pi-Shan Sung, Chih-Hung Chen. Management of Hyperacute Stroke during the Coronavirus Disease of 2019 Pandemic: The Modified Code Stroke in a Medical Center in Taiwan. Journal of stroke , 22(2):278-281. (Corresponding Author)
  8. Lee TL, Liu CH, Chang YM, Lin TY, Chien CY, Chen CH, Tsai KJ, Lin SH, Sung PS (2020, Jan). The Impact of Antiplatelet Use on the Risk of Intracerebral Hemorrhage in Patients with Alzheimer's Disease: A Nationwide Cohort Study.. Journal of Alzheimer's disease, 2020;73(1)297-306. (Corresponding Author)
  9. Pi-Shan Sung, Po-Yu Lin, Chi-Hung Liu, Hui-Chen Su, Kuen-Jer Tsai (2020, Jan). Neuroinflammation and Neurogenesis in Alzheimer’s Disease and Potential Therapeutic Approaches. International journal of molecular sciences, 21(3), 701. (First Author).
  10. Hui Hua Chang † , Pi-Shan Sung ,†, Wei Chen Liao , Alice Y. W. Chang , Ya-Hsin Hsiao , Tzu-Fun Fu , Chin-Ying Huang and Chin-Wei Huang (2020, Aug).An Open Pilot Study of the Effect and Tolerability of Add-On Multivitamin Therapy in Patients with Intractable Focal Epilepsy. Nutrients 12(8): 2359. (Co-First Author). Contrast-Induced Encephalopathy After Endovascular Thrombectomy for Acute Ischemic Stroke.Chu YT, Lee KP, Chen CH, Sung PS, Lin YH, Lee CW, Tsai LK, Tang SC, Jeng JS. Stroke Oct.
  11. Maintenance of Stroke Care Quality amid the Coronavirus Disease 2019 Outbreak in Taiwan.Chen CH, Liu CH, Chi NF, Sung PS, Hsieh CY, Lee M, Tang SC, Jeng JS; Taiwan Stroke Society Investigators. J Stroke. 2020 ;22(3):407-411. 
  12. Innovative Head-Mounted System Based on Inertial Sensors and Magnetometer for Detecting Falling Movements.Lin CL, Chiu WC, Chu TC, Ho YH, Chen FH, Hsu CC, Hsieh PH, Chen CH, Lin CK, Sung PS, Chen PT. Sensors (Basel). 2020 Oct 12;20(20):5774
  13. Increased leptin-b expression and metalloprotease expression contributed to the pyridoxine-associated toxicity in zebrafish larvae displaying seizure-like behavior.Chen PY, Tsai YW, Chang AY, Chang HH, Hsiao YH, Huang CW, Sung PS, Chen BH, Fu TF. Biochem Pharmacol. 2020 Oct 17;182:114294
  14. Pioglitazone and PPAR-γ modulating treatment in hypertensive and type 2 diabetic patients after ischemic stroke: a national cohort study. Liu CH, Lee TH, Lin YS, Sung PS, Wei YC, Li YR. Cardiovasc Diabetol. 2020 Jan 7;19(1):2
  15. Effects of walking on sundown syndrome in community-dwelling people with Alzheimer's disease.Shih YH, Pai MC, Lin HS, Sung PS, Wang JJ.Int J Older People Nurs. 2020 Jun;15(2):e12292.
  16. Detrimental effects of intracerebral haemorrhage on patients with CADASIL harbouring NOTCH3 R544C mutation. Chen CH, Tang SC, Cheng YW, Tsai HH, Chi NF, Sung PS, Yeh HL, Lien LM, Lin HJ, Lee MJ, Hu CJ, Chiou HY, Jeng JS. J Neurol Neurosurg Psychiatry. 2019 Jul;90(7):841-843.
  17. Brain computerized tomography reading in suspected acute ischemic stroke patients: what are essentials for medical students? Liu CH, Hsiao CT, Chang TY, Chang YJ, Kuo SH, Chang CW, Chen CJ, Chen CF, Cheng PL, Chin SC, Chiu TF, Hsu JL, Hsu PW, Lee TH, Liao CH, Lin CJ, Lin LH, Seak CJ, Sung PS, Yang TC, Wu YM.BMC Med Educ. 2019 Sep 18;19(1):359.
  18. Sodium Metabisulfite: Effects on Ionic Currents and Excitotoxic ity.. , Lai MC, Hung TY, Lin KM, Sung PS, Wu SJ, Yang CS, Wu YJ, Tsai JJ, Wu SN, Huang CW. Neurotox Res. 2018 Jul;34(1):1-15.
  19. Yang CM, Hung CL, Su HC, Lin HJ, Chen CH, Lin CC, Hu HH, Lin SH, Sung PS (2018, May). Leukoaraiosis and risk of intracranial hemorrhage and outcome after stroke thrombolysis.. , 13(5):e0196505. (Corresponding Author)
  20. Chang YM, Huang CY, Su HC, Chen CH, Sung PS (2018, Mar). Delayed Endovascular Thrombectomy in a Patient Suffering from Stroke in Progression after Intravenous Thrombolytic Therapy. . Acta Neurologica Taiwanica, 27(1):18-21.. (Corresponding Author)
  21. Yang YH, Wu MN, Chou PS, Su HC, Lin SH, Sung PS* (2018, Mar). Longitudinal Neuropsychological Outcome in Taiwanese Alzheimer's Disease patients treated with medication. . Current Alzheimer Research , 15(5): 474-481. (Corresponding Author)
  22. Sung PS, Yeh CC, Wang LC, Hung PH, Muo CH, Sung FC, Chen CH, Tsai KJ. (2017, Mar). Increased Risk of Dementia in Patients with Non-Apnea Sleep Disorder.. , 14(3):309-316. (First Author)
  23. Sun MC, Lai TB, Jeng JS, Sung SF, Sung PS, Tang SC, Chen WL, Chen CH. (2015, Jan). Safety of intravenous thrombolysis for ischaemic stroke in Asian octogenarians and nonagenarians.. Age Ageing., 44(1):158-61.
  24. Huang CY, Li YC, Wang HK, Sung PS, Wang LC, Sun YT, Pan CH, Tsai KJ. (2015). Stroke suggests increased risk of dementia. Current Alzheimer research , 12(3):287-95. .
  25. Huang LC, Tsai KJ, Wang HK, Sung PS, Wu MH, Hung KW, Lin SH. (2014, Dec). Prevalence, incidence, and comorbidity of clinically diagnosed obsessive-compulsive disorder in Taiwan: A national population-based study. . Psychiatry Research, 220(1-2):335-41.
  26. Chuang MT, Lin CC, Sung PS, Su HC, Chen YC, Liu YS. (2014, Sep). Diffusion-weighted imaging as an aid in the diagnosis of the etiology of medial longitudinal fasciculus syndrome.. Surgical radiological Anatomy , 36(7):675-80..
  27. Hsieh CY, Sung PS, Hwang WJ. (2014, Sep). Transient blepharospasm, apraxia of eyelid opening, and hemidyskinesia following a right parietotemporal infarct. . Parkinsonism Related Disorder , 20(9):1024-6 .
  28. Hung PH, Huang YT, Hsiao CY, Sung PS, Guo HR, Tsai KJ. (2014, Apr). Young stroke patients are at high risk for subsequent end-stage renal disease: a population-based observational study. . Nephrology dialysis transplantation , 29(4):873-8..
  29. Lu K, Wang HK, Yeh CC, Huang CY, Sung PS, Wang LC, Muo CH, Sung FC, Chen HJ, Li YC, Chang LC, Tsai KJ. (2014, Apr). Association between autoimmune rheumatic diseases and the risk of dementia.. Biomedical research international , 2014:861812 .
  30. Tsai MC, Tsai KJ, Wang HK, Sung PS, Wu MH, Hung KW, Lin SH. (2014, Jan). Mood disorders after traumatic brain injury in adolescents and young adults: a nationwide population-based cohort study. . Journal of pediatrics , 164(1):136-141..
  31. Hwang WJ, Chen JY, Sung PS, Lee JC. (2014). Parkinsonian tremor-induced electrocardiographic artifacts mimicking atrial flutter/fibrillation or ventricular tachycardia.. Internal journal of cardiology, 173(3):597-600.
  32. Hsieh HC, Hsieh CY, Lin CH, Sung PS, Li CY, Chi CH, Chen CH (2013, May). Development of an educational program for staffs of emergency medical service to improve their awareness of stroke within 3 hours of symptom onset: a pilot study. . Acta Neurologica Taiwanica , 22(1):4-12.
  33. Wang HK, Lin SH, Sung PS, Wu MH, Hung KW, Wang LC, Huang CY, Lu K, Chen HJ, Tsai KJ. (2012, Nov). Population based study on patients with traumatic brain injury suggests increased risk of dementia. . Journal of Neurology, Neurosurgery and psychiatry , 83(11):1080-5.
  34. Sung PS, Chen CH, Hsieh HC, Fang CW, Hsieh CY, Sun YT, Hwang WJ. (2011, Aug). Outcome of Acute Ischemic Stroke in Very Elderly Patients: Is Intravenous Thrombolysis Beneficial? . European Neurology . (First Author)
  35. Sung PS, Fang CW, Chen CH. (2010, Jul). Acute aortic dissection mimicking basilar artery occlusion in a case presenting sudden coma. . Journal of clinical neuroscience., 17(7): 952-953. (First Author)
  36. Hsieh CY, Sung PS, Tsai JJ, Huang CW. (2010, May). Terminating prolonged refractory status epilepticus using ketamine. . Clinical Neuropharmacology , 33(3):165-167 .
  37. Sung PS, Lin TS. (2010, Jan). Asymmetrical delayed encephalopathy after acute CO intoxication: a case report. NeuroToxicology , 31(1):161-163 . (First Author and Corresponding author)
  38. Sung PS, Pai MC. (2008, Dec). Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy. . Acta Neurologica Taiwanica , 17(4):305-306 . (First Author)

Conference paper:

  1. Pi-Shan Sung, Y.M. Chang, H.C. Su, H.C. Hsieh, S.H. Lin, C.H. Chen. The risk of intracranial hemorrhage in Alzheimer’s disease patients treated with antiplatelet therapy (World Stroke Congress, 2018)
  2. Hui-Chen Su, Yu-Ming Chang, Chih-Yuan Huang, Ming-Tsung Chuang, Pi-Shan Sung* Recurrent posterior circuation ischemic stroke resulting from os Odontoideum with atlantoaxial dislocation. (Taiwan Stroke Society, 2017)
  3. Chao-Yu Ting, Yi-Shan Lin, Tsung-Lin Li, Che-Chun Yeh, Yi-Te Tsai, Yi-jen Wu, Pi-Shan Sung*. Irreversible cholestatic liver injury in a super-refractory status epilepticus patient with prolonged ketamine use. (Annual meeting of Taiwan Neurological society, 2017)
  4. Yi-Te Tsai, Pi-Shan Sung* Cerebral microbleeds on post-thrombolytic therapy MRI may indicate poor functional outcome but not symptomatic intracranial hemorrhage. Our experience in a university hospital. (Annual meeting of Taiwan Neurological society, 2017)
  5. Tsai-Hsuan Chen, Pi-Shan Sung* Cerebrotendinous Xanthomatosis : A Case Report. (Annual meeting of Taiwan Neurological society, 2017)
  6. Pi-Shan Sung, Chun-Ming Yang,Hui-Chen Su, Huey-Juan Lin, Chih-Hung Chen. The association of leukoaraiosis and symptomatic intracranial hemorrhage and functional outcome in patients receiving intravenous thrombolysis. (Taiwan Stroke Society, 2016)
  7. Pi-Shan Sung, Hui-Chen Su, Tien-Yu Lin, Chung Yao Chien, Chih-Hung Chen. White matter hyperintensity predicts poor functional outcome in lacunar stroke patients with diabetes mellitus. (Asia Pacific Stroke Conference, 2015)
  8. Pi-Shan Sung, Chih-Hung Chen, Kuen-Jer Tsai. Nanocurcumin reduced focal ischemic injury and improved outcomes in rat stroke model. (Asia Pacific Stroke Conference, 2014)
  9. Han-Chieh Hsieh, Cheng-Yang Hsieh, Pi-Shan Sung, Chih-Hung Chen. Results of an educational program for medical personnel in the Southern Medical District Network. (Taiwan Stroke Society,2012)
  10. Pi-Shan Sung, Han-Chieh Hsieh, Cheng-Yang Hsieh, Chih-Hao Lin, Huey-Juan Lin, Shang-Te Wu, Ray-Chang Tzeng , Chih-Hung Chen.The accuracy of acute stroke identification of Emergency Medical Service (EMS) Staff in the pre-hospital setting. (Taiwan Stroke Society, 2011)
  11. Pi-Shan Sung, Chih-Hung-Chen, Han-Chieh Hsieh, Chen-Wen Fang, Cheng-Yang Hsieh, Ling-Chien Hung,Chih-Sheng Yang, Yi-Jen Wu. Intravenous Tissue Plasminogen Activator for Ischemic Stroke in The Elderly (World Stroke Congress, 2010)
  12. Chung Yao Chien, Hui-Chen Su, Cheng-Wen Fang, Pi-Shan Sung, Chih-Hung Chen. Intravenous thrombolytic therapy in an acute ischemic stroke patient with severe heart failure: A case report. (Annual Meeting of Taiwan Neurological Society , 2010)
  13. Pi-Shan Sung , Chih-Hung-Chen. Clinical outcome of cerebral ischemic patients with initial minor symptoms. (Annual Meeting of Taiwan Neurological Society , 2009)